J Phys Chem A. 2009 Mar 5;113(9):1674-7. doi: 10.1021/jp810466y.
We introduce a new technique to measure tracer dynamics, which is sensitive to single metal nanoparticles down to a radius of 2.5 nm with a time resolution of a few microseconds. It is based on a fluctuation analysis of a heterodyne photothermal scattering signal emanating from the hot halo around the laser-heated tracer. A generalized Stokes-Einstein relation for "hot brownian motion" is developed and verified. Exploiting the excellent photostability of gold nanoparticles, the developed method promises broad applications especially in the field of quantitative biomedical screening.
我们介绍了一种新的技术来测量示踪剂动力学，该技术对半径为 2.5nm 的单个金属纳米粒子具有敏感性，时间分辨率为几微秒。它基于从激光加热示踪剂周围的热晕中发出的外差光热散射信号的涨落分析。开发并验证了“热布朗运动”的广义斯托克斯-爱因斯坦关系。利用金纳米粒子优异的光稳定性，开发的方法有望得到广泛应用，特别是在定量生物医学筛选领域。
