Discovery Medicinal Chemistry, Chemical Sciences, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA.
Org Lett. 2009 Mar 5;11(5):1183-5. doi: 10.1021/ol900036y.
An efficient and mild method to couple aryl bromides and activated non-allylic alcohols in a Heck reaction with tandem isomerization to selectively afford high yields of 1,5-diarylalkan-1-ones has been developed. Mechanistic insight was gained through NMR studies of products derived from deuterium-labeled intermediates.
发展了一种 Heck 反应中高效且温和的方法，用于偶联芳基溴化物和活化的非烯丙醇，并进行串联异构化，以高收率选择性地得到 1,5-二芳基-1-酮。通过对氘标记中间体衍生的产物的 NMR 研究获得了对反应机理的深入了解。
