高效、区域选择性钯催化的芳基溴化物和非烯丙基苄醇的串联 Heck-异构化反应。
Efficient, regioselective palladium-catalyzed tandem Heck-isomerization reaction of aryl bromides and non-allylic benzyl alcohols.
机构信息
Discovery Medicinal Chemistry, Chemical Sciences, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA.
出版信息
Org Lett. 2009 Mar 5;11(5):1183-5. doi: 10.1021/ol900036y.
PMID:19209924
Abstract
An efficient and mild method to couple aryl bromides and activated non-allylic alcohols in a Heck reaction with tandem isomerization to selectively afford high yields of 1,5-diarylalkan-1-ones has been developed. Mechanistic insight was gained through NMR studies of products derived from deuterium-labeled intermediates.
摘要
发展了一种 Heck 反应中高效且温和的方法，用于偶联芳基溴化物和活化的非烯丙醇，并进行串联异构化，以高收率选择性地得到 1,5-二芳基-1-酮。通过对氘标记中间体衍生的产物的 NMR 研究获得了对反应机理的深入了解。
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