γ-疱疹病毒诱导的针对细菌感染的保护作用是短暂的。
gamma-Herpesvirus-induced protection against bacterial infection is transient.
作者信息
Yager Eric J, Szaba Frank M, Kummer Larry W, Lanzer Kathleen G, Burkum Claire E, Smiley Stephen T, Blackman Marcia A
机构信息
Trudeau Institute, Saranac Lake, New York 12983, USA.
出版信息
Viral Immunol. 2009 Feb;22(1):67-72. doi: 10.1089/vim.2008.0086.
Abstract
Herpesviruses are widely disseminated in the population and establish lifelong latency, which is associated with a variety of pathological consequences. A recent report showed that mice latently infected with either murine gamma-herpesvirus-68 (gammaHV68) or murine cytomegalovirus (mCMV), mouse pathogens genetically similar to the human herpesviruses, Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus, and cytomegalovirus, had enhanced resistance to subsequent bacterial infection, suggesting protective as well as deleterious effects of latency. Here we confirm that latent gammaHV68 infection confers protection against subsequent infection with Listeria monocytogenes. However, the effect is transient, lasting only a few months.
摘要
疱疹病毒在人群中广泛传播并建立终身潜伏感染，这与多种病理后果相关。最近的一份报告显示，潜伏感染鼠γ-疱疹病毒68（γHV68）或鼠巨细胞病毒（mCMV）的小鼠，这两种小鼠病原体在基因上分别与人疱疹病毒、爱泼斯坦-巴尔病毒、卡波西肉瘤相关疱疹病毒和巨细胞病毒相似，对随后的细菌感染具有增强的抵抗力，这表明潜伏感染具有保护作用以及有害影响。在这里，我们证实潜伏的γHV68感染可对随后的单核细胞增生李斯特菌感染提供保护。然而，这种效果是短暂的，仅持续几个月。
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