Nomura Tadashi, Hattori Mitsuharu, Osumi Noriko
Department of Cell and Molecular Biology, Karolinska Institute, 171-77 Sweden.
Dev Growth Differ. 2009 Apr;51(3):287-97. doi: 10.1111/j.1440-169X.2008.01073.x. Epub 2008 Dec 19.
The mammalian cerebral cortex has a remarkable laminated structure, which is derived from the pallium, the dorsal part of the embryonic telencephalon. Recent studies indicate that the pallium is developed as a homologous structure in all vertebrate species. However, the cellular and molecular mechanism for making architectural diversity of the pallium is not fully understood. Here we introduce recent progress in comparative analysis of pallial development, and our data on the role of Reelin protein in the developing avian pallium. These experimental approaches to pallial development in non-mammalian species will provide a new insight into evolution of the cerebral cortex.
哺乳动物的大脑皮层具有显著的分层结构，该结构源自胚胎端脑背侧部分的大脑皮质。最近的研究表明，大脑皮质在所有脊椎动物物种中都是作为同源结构发育而来的。然而，导致大脑皮质结构多样性的细胞和分子机制尚未完全明确。在此，我们介绍大脑皮质发育比较分析的最新进展，以及我们关于Reelin蛋白在发育中的鸟类大脑皮质中作用的数据。这些针对非哺乳动物物种大脑皮质发育的实验方法将为大脑皮层的进化提供新的见解。
