Pelikan Zdenek
Allergy Research Foundation, Breda, The Netherlands.
Curr Allergy Asthma Rep. 2009 Mar;9(2):107-13. doi: 10.1007/s11882-009-0016-3.
Nasal allergy seems to be one of the important causes of chronic secretory otitis media (SOM) in children and adults. Chronic SOM is unequivocally related to disturbed function of the eustachian tube, which facilitates communication of the middle ear with the nasopharynx, nasal cavity, and indirectly with paranasal sinuses. The most serious consequences of chronic SOM are decreased elasticity of the tympanic membrane and hearing impairment. Allergic reactions in the nasal mucosa leading to release of various mediators result in development of three types of nasal response characterized predominantly by nasal obstruction. Eustachian tube functions can be affected directly by the mediators released in the nasal mucosa or indirectly by the nasal obstruction. Nasal challenges with allergens performed by rhinomanometry, combined with tympanometry and eventually audiometry, may be a useful diagnostic supplement for this disorder.
鼻过敏似乎是儿童和成人慢性分泌性中耳炎(SOM)的重要病因之一。慢性SOM与咽鼓管功能紊乱明确相关,咽鼓管促进中耳与鼻咽、鼻腔以及间接与鼻窦之间的连通。慢性SOM最严重的后果是鼓膜弹性降低和听力损害。鼻黏膜中的过敏反应导致各种介质释放,引发三种主要以鼻塞为特征的鼻反应类型。咽鼓管功能可直接受到鼻黏膜中释放的介质影响,或间接受到鼻塞影响。通过鼻阻力测量法进行的过敏原鼻激发试验,结合鼓室导抗图检查,最终进行听力测定,可能是该疾病有用的诊断补充方法。