Brown Z, Strieter R M, Chensue S W, Ceska M, Lindley I, Neild G H, Kunkel S L, Westwick J
Department of Renal Medicine, University College, Middlesex School of Medicine, London, United Kingdom.
Kidney Int. 1991 Jul;40(1):86-90. doi: 10.1038/ki.1991.184.
Human mesangial cells (MC) in culture, when stimulated by interleukin 1 alpha(IL-1 alpha) or tumour necrosis factor (TNF alpha), but not with lipopolysaccharide (LPS), express interleukin 8 (IL-8) mRNA, and both cell associated and extracellular IL-8. Dexamethasone treatment of mesangial cells induced partial inhibition of the release of extracellular IL-8, while cell-associated IL-8 and IL-8 mRNA were not significantly altered. We propose that the mesangial cell has a direct role in the initiation and propagation of inflammatory events within the glomerulus via the generation of the chemotactic cytokine IL-8.
培养的人系膜细胞（MC）在受到白细胞介素1α（IL-1α）或肿瘤坏死因子（TNFα）刺激时（而非脂多糖（LPS）刺激），会表达白细胞介素8（IL-8）信使核糖核酸（mRNA），以及细胞相关和细胞外的IL-8。地塞米松处理系膜细胞可部分抑制细胞外IL-8的释放，而细胞相关的IL-8和IL-8 mRNA则无明显变化。我们认为，系膜细胞通过产生趋化细胞因子IL-8，在肾小球内炎症事件的起始和传播中起直接作用。
