Cappuccio F P, Markandu N D, MacGregor G A
Department of Medicine, St. George's Hospital Medical School, London, U.K.
Klin Wochenschr. 1991;69 Suppl 25:17-25.
There is much circumstancial and some direct evidence in humans to suggest that a high consumption of salt predisposes communities and individuals to the development of essential hypertension. Restriction of salt intake in the diet lowers blood pressure in many subjects with high blood pressure and this fall in blood pressure is mediated in part by a diminished renin response to sodium restriction as hypertension develops. The effect of sodium restriction, like diuretics, is additive to many blood pressure lowering drugs, particularly those that inhibit the renin system such as beta-blockers and angiotensin converting enzyme inhibitors.
在人类中有很多间接证据以及一些直接证据表明，高盐摄入会使群体和个体更易患原发性高血压。饮食中限制盐的摄入量可使许多高血压患者的血压降低，并且随着高血压的发展，这种血压下降部分是由肾素对钠限制的反应减弱介导的。与利尿剂一样，限制钠的作用与许多降压药物具有相加作用，尤其是那些抑制肾素系统的药物，如β受体阻滞剂和血管紧张素转换酶抑制剂。
