MacGregor G A
Scand J Clin Lab Invest Suppl. 1985;176:25-37.
Moderate salt restriction lowers blood pressure in many patients with essential hypertension. The effectiveness of the salt restriction in lowering blood pressure appears to be directly related to the severity of the blood pressure and suppression of the renin-angiotensin system. Patients with more severe hypertension, older patients or black patients will respond best. Salt restriction is additive to the effect of blood pressure lowering drugs particularly those that block the renin-angiotensin system such as beta-blockers and converting enzyme inhibitors. All patients with high blood pressure and, particularly those already on drug treatment, should be instructed on how to cut back their salt intake moderately. Most patients find it easy to reduce salt intake to around half of their present consumption.
适度限制盐摄入可降低许多原发性高血压患者的血压。限制盐摄入降低血压的效果似乎与血压严重程度及肾素-血管紧张素系统的抑制直接相关。高血压更严重的患者、老年患者或黑人患者反应最佳。限制盐摄入与降压药物的效果具有相加作用,尤其是那些阻断肾素-血管紧张素系统的药物,如β受体阻滞剂和转换酶抑制剂。所有高血压患者,尤其是那些已经接受药物治疗的患者,都应接受如何适度减少盐摄入量的指导。大多数患者发现将盐摄入量减少到目前摄入量的一半左右很容易。