Krekels M M, de Leeuw P W
Afd. Algemene Interne Geneeskunde, Academisch Ziekenhuis, Maastricht.
Ned Tijdschr Geneeskd. 1997 Nov 22;141(47):2285-9.
The relationship between (excessive) use of sodium chloride and the blood pressure is still equivocal. Blood pressure responses to alterations in dietary salt consumption vary greatly between individuals, which has led to the concept of salt sensitivity. Although the mechanisms which determine the degree of salt sensitivity are not fully understood, the renin-angiotensin system seems to play a key role. A relative inability of this system to respond promptly to alterations in salt intake may underlie the development of salt sensitivity. By administering drugs which block the renin-angiotensin system to patients with essential hypertension, blood pressure is rendered more sensitive to the effects of salt restriction and (or) diuretic treatment.
氯化钠（过量）摄入与血压之间的关系仍不明确。个体对饮食中盐摄入量变化的血压反应差异很大，这导致了盐敏感性的概念。尽管决定盐敏感程度的机制尚未完全了解，但肾素 - 血管紧张素系统似乎起着关键作用。该系统相对无法对盐摄入量的变化迅速做出反应可能是盐敏感性发展的基础。通过给原发性高血压患者使用阻断肾素 - 血管紧张素系统的药物，血压对限盐和（或）利尿剂治疗的效果变得更加敏感。
