McCarron D A, Luft F C
Abteilung Nephrologie und Hypertonie, NIDDK Clinical Nutrition Research Unit, Oregon Health Science University, Portland.
Klin Wochenschr. 1991;69 Suppl 25:97-102.
Nonpharmacologic approaches to patients with hypertension are a worthwhile avenue to treatment as well as a laudable public health goal. Reduced salt intake has been the primary dietary measure. However, recently attention has also been directed at potassium, calcium, magnesium, and the anions accompanying these cations. Further, the importance of total caloric intake and confounding dietary variables such as alcohol consumption have been appreciated. It is important to recognize that nutrients are not ingested in isolation, but rather as interactive constituents of a total diet. This principle may account for some of the heterogeneity of the human blood pressure response to variations of individual electrolyte intake. Moreover, failure to appreciate this heterogeneity and interactive effects may result in other than the desired effect in the population at risk.
对于高血压患者而言，非药物治疗方法不仅是一种值得尝试的治疗途径，也是一个值得称赞的公共卫生目标。减少盐摄入量一直是主要的饮食措施。然而，近来人们也开始关注钾、钙、镁以及这些阳离子所伴随的阴离子。此外，总热量摄入以及诸如饮酒等混杂饮食变量的重要性也已得到认识。必须认识到，营养素并非孤立摄入，而是作为整个饮食中相互作用的成分。这一原则可能解释了人类血压对个体电解质摄入量变化反应的一些异质性。此外，未能认识到这种异质性和相互作用效应可能会在高危人群中产生非预期的效果。
