Mehrotra R, Hullmann M, Smeets R, Reichert T E, Driemel O
Department of Pathology, Moti Lal Nehru Medical College, Allahabad, India.
J Oral Pathol Med. 2009 Feb;38(2):161-6. doi: 10.1111/j.1600-0714.2008.00709.x.
During the last decade, oral cytology has once again become the focus of scientific research. This new interest is due to the introduction of a cytobrush for cell collection as well as a computer-assisted analysis (Oral CDx). Although promising, the sensitivity and specificity of conventional oral brush cytology remains limited. To circumvent the problems and improve the accuracy, various adjunctive analytical methods have been attempted. DNA analysis, immunocytochemical and molecular analysis are suggested methodological cytology approaches to improve the validity of oral brush cytology. An increase in sensitivity (up to 100%) and specificity (up to 100%) of oral brush biopsy has been reported on localized pre-malignant and malignant lesions. Oral brush biopsy probably will not replace histopathology in the definitive diagnosis of oral cancer, but it might be valuable for the prevention of misdiagnosis of clinically doubtful oral lesions and for the monitoring of lesions that might proceed on to oral cancer.
在过去十年中，口腔细胞学再次成为科研焦点。这种新的关注源于用于细胞采集的细胞刷以及计算机辅助分析（口腔CDx）的引入。尽管前景广阔，但传统口腔刷片细胞学的敏感性和特异性仍然有限。为了规避这些问题并提高准确性，人们尝试了各种辅助分析方法。DNA分析、免疫细胞化学和分子分析是被建议用于提高口腔刷片细胞学有效性的方法学细胞学途径。据报道，对于局限性癌前病变和恶性病变，口腔刷检活检的敏感性（高达100%）和特异性（高达100%）有所提高。口腔刷检活检可能无法在口腔癌的明确诊断中取代组织病理学，但对于预防临床可疑口腔病变的误诊以及监测可能发展为口腔癌的病变可能具有重要价值。
