Hansen Troels Krarup, Gall Mari-Anne, Tarnow Lise, Thiel Steffen
Immunendokrinologisk Forskningsenhed, Medicinsk Afdeling M, Arhus Sygehus.
Ugeskr Laeger. 2009 Feb 2;171(6):426-9.
We evaluated the relationship between serum mannose-binding lectin (MBL) and mortality and incident albuminuria in 326 patients with type 2 diabetes mellitus (T2DM). During 15 years of follow-up, 169 patients died. In a multivariate analysis, MBL was a significant risk factor for death from any cause and added to the predictive power of CRP. Normoalbuminuric patients with both high MBL and high C-reactive protein (CRP) levels had a significantly increased risk of developing albuminuria. We conclude that MBL alone or in combination with CRP can provide prognostic information on mortality and the development of albuminuria in T2DM
我们评估了326例2型糖尿病（T2DM）患者血清甘露糖结合凝集素（MBL）与死亡率及新发蛋白尿之间的关系。在15年的随访期间，169例患者死亡。多变量分析显示，MBL是任何原因导致死亡的显著危险因素，并增强了CRP的预测能力。MBL和C反应蛋白（CRP）水平均高的正常白蛋白尿患者发生蛋白尿的风险显著增加。我们得出结论，MBL单独或与CRP联合使用可为T2DM患者的死亡率及蛋白尿发生情况提供预后信息。
