Morikawa Y, Fujimoto K, Okada T
Department of Veterinary Anatomy, College of Agriculture, University of Osaka Prefecture, Japan.
Lab Anim. 1991 Jul;25(3):242-6. doi: 10.1258/002367791780808347.
Perinatal changes in the apical surface of the colonic absorptive cells in the rat were studied morphometrically. Cell microvilli length increased from day 20 through neonatal day 3, during which a maximum incremental growth rate was noted between fetal day 22 and neonatal day 1. Microvilli width remained almost constant throughout the period. Enlargement of the apical surface of the microvilli showed a similar developmental pattern as was seen from the measurement of length and surface area of any one of the microvilli. Fetal oral administration of milk in utero caused incremental growth in length and surface area, as well as an associated apical surface enlargement. The present study indicates that the function of the colonic absorptive cells, which is acquired later on in utero, is activated by ingestion of maternal milk after birth.
对大鼠结肠吸收细胞顶端表面的围产期变化进行了形态计量学研究。从胚胎第20天到出生后第3天，细胞微绒毛长度增加，在此期间，在胚胎第22天到出生后第1天之间观察到最大增量生长率。微绒毛宽度在此期间几乎保持恒定。微绒毛顶端表面的增大显示出与从任何一根微绒毛的长度和表面积测量中看到的相似的发育模式。在子宫内给胎儿口服牛奶会导致长度和表面积的增量生长，以及相关的顶端表面增大。本研究表明，子宫内后期获得的结肠吸收细胞功能在出生后通过摄入母乳而被激活。
