Reusens-Billen B, Remacle C, Hoet J J
Laboratory of Cell Biology, University of Louvain, Louvain-la-Neuve, Belgium.
Diabetes Res Clin Pract. 1989 Apr 1;6(3):199-211. doi: 10.1016/0168-8227(89)90030-2.
In rodents, the fetal intestine develops rapidly during the last 5 days of gestation. The present investigation describes the events which occur in the duodenum, jejunum and ileum of fetal Wistar rat from day 16.5 to 21.5. The first villi and microvilli as well as endocrine cells already appear at 17.5 days in the duodenal mucosae. Goblet cells are detected at 18.5 days. The structure of the intestinal mucosa at 21.5 days is similar to that of adults. The evolution was quantified by morphometric analysis. The external and inner circumference, the length of the villi profile and the increased absorption area due to the villi profile were measured. We demonstrated that the total enlargement of the luminal surface area due to the villi and the microvilli in the duodenum of the fetus at 21.5 days is similar to that in the adult duodenum. This morphometric analysis could be used to detect possible disturbances in the development of the fetal intestine.
在啮齿动物中，胎儿肠道在妊娠的最后5天迅速发育。本研究描述了胎龄16.5至21.5天的Wistar大鼠胎儿十二指肠、空肠和回肠中发生的事件。十二指肠黏膜在17.5天时已出现第一批绒毛、微绒毛以及内分泌细胞。18.5天时检测到杯状细胞。21.5天时肠道黏膜结构与成年动物相似。通过形态计量分析对发育过程进行了量化。测量了外周和内周、绒毛轮廓长度以及绒毛轮廓增加的吸收面积。我们证明，21.5天胎儿十二指肠中绒毛和微绒毛导致的管腔表面积总增大与成年十二指肠相似。这种形态计量分析可用于检测胎儿肠道发育中可能存在的紊乱情况。
