Gourgouliatos Z F, Welch A J, Diller K R
Biomedical Engineering Program, University of Texas, Austin 78712.
J Biomech Eng. 1991 Aug;113(3):301-7. doi: 10.1115/1.2894888.
A dorsal skin flap model for microcirculatory studies has been modified for "in vivo" studies of laser-tissue interaction with microcirculation. An experimental apparatus has been built implementing a laser delivery system, video microscopy during irradiation, and thermal recordings. This model has been used to study irradiation effects on microcirculation using the argon laser (488 and 514.5 nm) and the argon pumped dye laser at 577 nm. The results include: measurements of the optical properties of the model; dosimetry measurements for the production of embolized and stationary coaguli in arterioles and venules; and focal vessel disappearance of venules irradiated with the argon or the argon pumped dye laser at 577 nm; a method to determine light attenuation in the model; a unique method for measurements of blood flow velocity in arterioles and venules and measurements obtained with this method; measurements of transient and steady state temperatures during irradiation and a study of laser induced photorelaxation phenomena in venules.
一种用于微循环研究的背部皮肤瓣模型已被改进，用于激光与微循环相互作用的“体内”研究。已构建了一个实验装置，该装置包括激光传输系统、照射过程中的视频显微镜以及热记录。该模型已被用于研究使用氩激光（488和514.5纳米）和577纳米的氩泵浦染料激光对微循环的照射效果。结果包括：模型光学特性的测量；小动脉和小静脉中产生栓塞性和静止性凝块的剂量测量；用577纳米的氩激光或氩泵浦染料激光照射的小静脉的局部血管消失；一种确定模型中光衰减的方法；一种测量小动脉和小静脉中血流速度的独特方法以及用该方法获得的测量结果；照射过程中瞬态和稳态温度的测量以及小静脉中激光诱导的光弛豫现象的研究。
