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印度北方儿童中乳糜泻的患病率。

Prevalence of celiac disease in north Indian children.

机构信息

Department of Pediatrics, Maulana Azad Medical College and Lok Nayak Hospital, Delhi 110 002, India.

出版信息

Indian Pediatr. 2009 May;46(5):415-7. Epub 2009 Jan 21.

Abstract

Celiac disease (CD) is being increasingly reported from the wheat-eating population of north India. However, the exact prevalence of CD in children is not known as population screening studies are scarce. Our study aimed to determine the prevalence of CD in 400 children, 6 months to 12 years of age attending pediatrics department of a tertiary care hospital in north India. The study population was screened for antitissue transglutaminase (tTG) antibodies. Endoscopic duodenal biopsy was done in the anti--tTG positive subjects. Four patients were diagnosed with CD as per the modified ESPGHAN criteria. The prevalence of CD thus was 1 %, which was in concordance with screening studies using serological markers conducted in the West.

摘要

在喜食小麦的印度北部人群中,乳糜泻(Celiac disease,CD)的报道日益增多。然而,由于人群筛查研究较为匮乏,儿童中 CD 的确切患病率尚不清楚。本研究旨在确定印度北部一家三级护理医院儿科就诊的 400 名 6 个月至 12 岁儿童的 CD 患病率。研究人群接受了抗组织转谷氨酰胺酶(tissue transglutaminase,tTG)抗体的筛查。在抗 tTG 阳性的患者中进行了内镜十二指肠活检。根据改良的 ESPGHAN 标准,有 4 例患者被诊断为 CD。因此,CD 的患病率为 1%,与在西方使用血清学标志物进行的筛查研究结果一致。

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