Gastroenterology and Liver Disease Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Science, Tehran, Iran.
Departments of Gastroenterology, Mid Central DHB, Palmerston Hospital, Palmerston North, New Zealand.
Sci Rep. 2021 Jan 27;11(1):2383. doi: 10.1038/s41598-021-82023-8.
This systematic review and meta-analysis study was conducted to estimate the pooled prevalence of CD in low and high risk groups in this region. Following keywords were searched in the Medline, PubMed, Scopus, Web of Science and Cochrane database according to the MeSH terms; celiac disease, prevalence, high risk population and Asian-Pacific region. Prevalence studies published from January 1991 to March 2018 were selected. Prevalence of CD with 95% confidence interval (CI) was calculated using STATA software, version 14. The pooled sero-prevalence of CD among low risk group in Asia-Pacific region was 1.2% (95% CI 0.8-1.7%) in 96,099 individuals based on positive anti-tissue transglutaminase (anti-t-TG Ab) and/or anti-endomysial antibodies (EMA). The pooled prevalence of biopsy proven CD in Asia-Pacific among high and low risk groups was 4.3% (95% CI 3.3-5.5%) and 0.61% (95% CI 0.4-0.8%) in 10,719 and 70,344 subjects, respectively. In addition, the pooled sero-prevalence and prevalence of CD in general population was significantly higher in children compared with adults and it was significantly greater in female vs. male (P < 0.05). Our results suggest high risk individuals of CD are key group that should be specifically targeted for prevention and control measures, and screening may prove to have an optimal cost-benefit ratio.
本系统评价和荟萃分析研究旨在估计该地区低危和高危人群中 CD 的汇总患病率。根据 MeSH 术语，在 Medline、PubMed、Scopus、Web of Science 和 Cochrane 数据库中搜索以下关键词：乳糜泻、患病率、高危人群和亚太地区。选择了 1991 年 1 月至 2018 年 3 月发表的患病率研究。使用 STATA 软件，版本 14 计算 CD 的患病率，置信区间（CI）为 95%。亚太地区低危人群中 CD 的血清患病率基于阳性抗组织转谷氨酰胺酶（抗-tTG Ab）和/或抗内肌膜抗体（EMA），在 96099 人中为 1.2%（95%CI 0.8-1.7%）。亚太地区高、低危人群中经活检证实的 CD 患病率分别为 4.3%（95%CI 3.3-5.5%）和 0.61%（95%CI 0.4-0.8%），在 10719 人和 70344 人中。此外，与成年人相比，儿童的 CD 血清患病率和患病率均显著更高，女性高于男性（P<0.05）。我们的结果表明，CD 的高危人群是应该特别针对预防和控制措施的关键群体，筛查可能证明具有最佳的成本效益比。
