Melis M S, Sainati A R
Departamento de Biologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Brazil.
J Ethnopharmacol. 1991 Jul;33(3):257-62. doi: 10.1016/0378-8741(91)90086-s.
A study conducted on rats using classical clearance techniques and arterial pressure measurements showed that stevioside from Stevia rebaudiana leaves produced a fall in systemic blood pressure, as well as diuresis and natriuresis per milliliter of glomerular filtration rate. Verapamil tended to increase the renal and systemic effects of stevioside. In contrast, an infusion of CaCl2 in rats prepared with stevioside induced a marked attenuation of the vasodilating responses of stevioside. These data are consistent with the possibility that stevioside may act as a calcium antagonist, as is the case for verapamil.
一项利用经典清除技术和动脉压测量方法在大鼠身上进行的研究表明，甜叶菊叶中的甜菊糖苷会导致全身血压下降，以及每毫升肾小球滤过率的利尿和利钠作用。维拉帕米倾向于增强甜菊糖苷的肾脏和全身效应。相比之下，在预先使用甜菊糖苷处理的大鼠中输注氯化钙会导致甜菊糖苷的血管舒张反应明显减弱。这些数据与甜菊糖苷可能像维拉帕米一样作为钙拮抗剂起作用的可能性是一致的。
