Melis M S
Departamento de Biologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Brazil.
J Ethnopharmacol. 1992 Jun;36(3):213-7. doi: 10.1016/0378-8741(92)90046-t.
Physiological and pharmacological experiments have suggested that stevioside from the leaves of Stevia rebaudiana acts as a typical systemic vasodilator. The effect of stevioside on renal function in both normal and with experimental renal hypertension rats (GII) was evaluated using clearance techniques. Stevioside provoked hypotension, diuresis and natriuresis in both the normal and hypertensive rats. Normal rats presented an increase in renal plasma flow (RPF) and glomerular filtration rate (GFR) constant following stevioside administration. The last effect is in part due to vasodilation of both the afferent and efferent arterioles. Moreover, stevioside infusion in hypertensive rats caused an increase in RPF and GFR. These data are consistent with impairment of a renal autoregulation mechanism in this experimental hypertensive model.
生理学和药理学实验表明，甜叶菊叶子中的甜菊糖苷是一种典型的全身性血管扩张剂。采用清除率技术评估了甜菊糖苷对正常大鼠和实验性肾性高血压大鼠（GII）肾功能的影响。甜菊糖苷在正常大鼠和高血压大鼠中均引起低血压、利尿和利钠作用。正常大鼠在给予甜菊糖苷后肾血浆流量（RPF）增加，肾小球滤过率（GFR）保持恒定。后一种作用部分归因于入球小动脉和出球小动脉的血管舒张。此外，向高血压大鼠输注甜菊糖苷会导致RPF和GFR增加。这些数据与该实验性高血压模型中肾自动调节机制受损一致。
