用钆（III）配合物靶向细胞表面蛋白硫醇。一种高效的磁共振成像细胞标记方法。
Targeting exofacial protein thiols with Gd(III) complexes. An efficient procedure for MRI cell labelling.
作者信息
Digilio Giuseppe, Catanzaro Valeria, Fedeli Franco, Gianolio Eliana, Menchise Valeria, Napolitano Roberta, Gringeri Concetta, Aime Silvio
机构信息
Department of Environmental and Life Sciences, University of Eastern Piedmont "A. Avogadro", Via Bellni 25G, 15100 Alessandria, Italy.
出版信息
Chem Commun (Camb). 2009 Feb 28(8):893-5. doi: 10.1039/b820593k. Epub 2009 Jan 26.
DOI:10.1039/b820593k
PMID:19214307
Abstract
Cells display on the outer surface of the plasma membrane a large number of protein thiols that can be reversibly labelled with suitably designed Gd(III)-based contrast agents for cell tracking by MRI.
摘要
细胞在质膜外表面展示出大量蛋白质硫醇，这些硫醇可以用经过适当设计的基于钆（III）的造影剂进行可逆标记，以便通过磁共振成像进行细胞追踪。
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