Caravan Peter
EPIX Pharmaceuticals, 67 Rogers St, Cambridge, MA 02142, USA.
Chem Soc Rev. 2006 Jun;35(6):512-23. doi: 10.1039/b510982p. Epub 2006 May 3.
Gadolinium(III) complexes are often used in clinical MRI to increase contrast by selectively relaxing the water molecules near the complex. There is a desire to improve the sensitivity (relaxivity) of these contrast agents in order to detect molecular targets. This tutorial review describes the molecular factors that contribute to relaxivity and illustrates with recent examples how these can be optimized. It may be of interest to senior undergraduates and more advanced researchers interested in lanthanide chemistry, biophysics, and/or molecular imaging.
钆（III）配合物常用于临床磁共振成像（MRI），通过选择性地使配合物附近的水分子弛豫来增强对比度。人们希望提高这些造影剂的灵敏度（弛豫率）以检测分子靶点。本教程综述描述了影响弛豫率的分子因素，并通过近期实例说明如何对其进行优化。对于对镧系元素化学、生物物理学和/或分子成像感兴趣的高年级本科生和更资深的研究人员而言，本文可能会有所助益。
