Solti F, Jellinek H, Schneider F, Lengyel E, Bérczi V, Kékesi V
Cardiovascular Surgical Clinic, Semmelweis Medical University, Budapest, Hungary.
Lymphology. 1991 Jun;24(2):54-9.
The effect of lymph stasis on the histological, biochemical, and elastic properties of the femoral artery were studied after regional lymphatic blockade in 36 dogs. Dogs were sacrificed 4-21 days after operation. Histologic changes of the femoral arterial wall (interstitial edema, degeneration in the muscle layer or media, thickened adventitia with dilated lymph vessels, and fibrosis) developed after regional lymphatic blockade. Characteristic metabolic alterations of the arterial wall (anaerobic catabolism of carbohydrate, increased lactate and glycosamine content) accompanied the morphological changes. Distensibility of the femoral artery decreased and greater elastic stiffness developed after regional lymphatic blockade. These results in conjunction with other experimental and clinical data support the concept that insufficient lymphatic transport within the blood vessel wall may contribute to the genesis and progression of arteriopathies.
在36只犬进行区域淋巴阻断后，研究了淋巴淤滞对股动脉组织学、生化及弹性特性的影响。术后4至21天处死犬。区域淋巴阻断后，股动脉壁出现组织学改变（间质水肿、肌层或中膜变性、外膜增厚伴淋巴管扩张及纤维化）。动脉壁特征性的代谢改变（碳水化合物的无氧分解、乳酸和氨基葡萄糖含量增加）伴随形态学改变。区域淋巴阻断后，股动脉的扩张性降低，弹性硬度增加。这些结果与其他实验和临床数据共同支持了这样一种观点，即血管壁内淋巴转运不足可能促成动脉病变的发生和发展。
