Mironov A A, Eremin G A, Vasilenko V A, Speranskiĭ N N
Arkh Anat Gistol Embriol. 1980 Oct;79(10):80-9.
The effect of sectioning the nephric lymphatic vessels on the functional morphology of its tissue elements has been studied in 125 dogs, providing that the other kidney, is preserved, as well as after contralateral nephrectomy and at autotransplantation. It has been stated that on the first postoperative days, in consequence of lymphostasis, protein resorption from the interstitial connective tissue is impeded. This results in stromal edema and in disturbed liquor transport performed by nephrocytes of the convoluted tubules. Protein retention in the interstilial connective tissue, despite the fact that lymph drainage is restored, produces formation of a slightly expressed diffuse nephric sclerosis with increasing number of collagenous fibrils, thickened basal membranes and accumulation of glycoproteids in them. Sectioning the nephric lymph vessels delays the development of compensatory hypertrophy signs in the nephric cellular elements. Nevertheless, as microcirculatory disturbances subside, hypertrophy and hyperplasy of cells and intracellular structures develop. Comparing dynamics of morphological changes in the autotransplanted kidney with that of a single kidney when its lymphatic vessels are cut, it is possible to conclude that it is the disorder in lymph drainage that causes a slight diffuse sclerosis in the transplanted kidney.
在125只犬身上研究了切断肾淋巴管对其组织成分功能形态的影响，条件是保留另一个肾脏，以及在对侧肾切除后和自体移植时。已经表明，在术后最初几天，由于淋巴淤滞，间质结缔组织的蛋白质吸收受到阻碍。这导致基质水肿和曲管肾细胞进行的液体转运紊乱。尽管淋巴引流恢复，但间质结缔组织中的蛋白质潴留会导致形成轻度弥漫性肾硬化，胶原纤维数量增加，基底膜增厚且其中糖蛋白积聚。切断肾淋巴管会延迟肾细胞成分中代偿性肥大体征的发展。然而，随着微循环紊乱消退，细胞和细胞内结构会出现肥大和增生。将自体移植肾与切断淋巴管的单肾形态学变化动态进行比较，可以得出结论，正是淋巴引流紊乱导致移植肾出现轻度弥漫性硬化。
