Grace Rachael F, Mednick Rachel E, Neufeld Ellis J
Division of Hematology/Oncology, Children's Hospital Boston, Boston, Massachusetts 02115, USA.
Pediatr Blood Cancer. 2009 Jul;52(7):865-7. doi: 10.1002/pbc.21961.
Overwhelming infection by encapsulated bacteria is a significant risk of splenectomy. Strict adherence to immunizations against encapsulated organisms is recommended. We performed a cross-sectional study to determine immunization status after splenectomy in the hereditary spherocytosis (HS) population. As HS is most often autosomal dominant, we used a strategy of ascertaining older affected individuals by expanding pedigrees from patients in our pediatric hematology center. Only 26% of asplenic patients reported receiving all recommended post-splenectomy vaccines. This study demonstrates that pediatric hematology clinics have a unique opportunity to provide or recommend catch-up and booster vaccinations to splenectomized adult relatives of their patients.
被包膜细菌的严重感染是脾切除术后的重大风险。建议严格坚持接种针对被包膜微生物的疫苗。我们进行了一项横断面研究，以确定遗传性球形红细胞增多症（HS）患者脾切除术后的免疫状况。由于HS大多为常染色体显性遗传，我们采用了一种策略，即通过扩大我们儿科血液学中心患者的家系来确定年龄较大的患病个体。只有26%的无脾患者报告接种了所有推荐的脾切除术后疫苗。这项研究表明，儿科血液学诊所拥有独特的机会，为其患者的脾切除成年亲属提供或推荐补种和加强疫苗接种。
