环氧苯乙烷在离体灌注大鼠肝脏中的代谢。主要代谢产物的鉴定与定量。
The metabolism of styrene oxide in the isolated perfused rat liver. Identification and quantitation of major metabolites.
作者信息
Ryan A J, Bend J R
出版信息
Drug Metab Dispos. 1977 Jul-Aug;5(4):363-7.
PMID:19215
Abstract
Isolated perfused rat livers rapidly metabolized 14C-styrene oxide. A large proportion of the administered radioactivity was excreted in the bile as a single compound that was identified as S-(1-phenyl-2-hydroxyethyl)glutathione by comparison with an authentic synthetic standard. The circulating perfusate was found to contain approximately equal amounts of styrene glycol, mandelic acid, and the glutathione derivative.
摘要
离体灌注的大鼠肝脏能迅速代谢14C-氧化苯乙烯。大部分给予的放射性物质以单一化合物的形式经胆汁排泄，通过与真实合成标准品比较，该化合物被鉴定为S-(1-苯基-2-羟乙基)谷胱甘肽。发现循环灌注液中含有等量的苯乙二醇、扁桃酸和谷胱甘肽衍生物。
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