Department of Psychiatry and Clinical Research Centre, Karoiinska Institute, S-141 86 Huddinge, Sweden.
J Neuroendocrinol. 1991 Oct 1;3(5):491-6. doi: 10.1111/j.1365-2826.1991.tb00308.x.
Abstract Deprivation of food reduced the level of dopamine in the cerebrospinal fluid of male rats and subsequent ingestion of food or intraperitoneal injection of Cholecystokinin octapeptide restored the level. Injection of a dopamine receptor agonist (apomorphine) or Cholecystokinin octapeptide inhibited food intake and these effects were reversed by pretreatment with a dopamine receptor antagonist (cis-flupentixol). Blockade of cholecystokinin-A receptors, by treatment with L-364,718, but not cholecystokinin-B receptors, by treatment with L-365,260, blocked the inhibitory effect of Cholecystokinin octapeptide on food intake but did not affect the inhibitory effect of apomorphine. It is suggested that Cholecystokinin interacts with dopamine in the control of food intake.
剥夺食物会降低雄性大鼠脑脊液中的多巴胺水平，随后摄入食物或腹腔内注射胆囊收缩素八肽会恢复其水平。注射多巴胺受体激动剂（阿扑吗啡）或胆囊收缩素八肽会抑制摄食，而这些作用可被多巴胺受体拮抗剂（顺式氟哌丁苯）预处理所逆转。用 L-364,718 阻断胆囊收缩素 A 受体，但用 L-365,260 阻断胆囊收缩素 B 受体，均可阻断胆囊收缩素八肽对摄食的抑制作用，但不影响阿扑吗啡的抑制作用。提示胆囊收缩素在摄食控制中与多巴胺相互作用。
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