Huang Y S, Doi R, Chowdhury P, Pasley J N, Nishikawa M, Huang T J, Rayford P L
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock 72205.
J Assoc Acad Minor Phys. 1993;4(2):56-8.
Effects of cholecystokinin octapeptide (CCK-8) on feeding behavior were examined in male and female rats. After an 18-hour fast, ad lib food intake for 30 minutes was measured for each rat. In male rats, food intake measured for 30 minutes was significantly decreased by intraperitoneal injection of 0.25 to 1 microgram/kg of CCK-8 in a dose-dependent manner. The satiety effect of CCK-8 was blocked by L-364,718 (20 nmol/kg), a specific cholecystokinin receptor antagonist. In female rats, food intake at proestrus and estrus was significantly less than that at diestrus. Food intake of female rats at diestrus and metestrus was significantly decreased by an intraperitoneal injection of CCK-8 prior to feeding, but it was not affected at proestrus and estrus. The effect of CCK-8 on food intake at diestrus and metestrus was dose dependent and was nearly abolished when 20 nmol/kg of L-364,718 was administered simultaneously. The results of this study suggest that stages of the estrous cycle affect feeding behavior of rats. Further, cholecystokinin's regulatory action on feeding behavior appears to be effective at diestrus and metestrus, but not at proestrus and estrus.
在雄性和雌性大鼠中研究了八肽胆囊收缩素（CCK - 8）对摄食行为的影响。禁食18小时后，测量每只大鼠30分钟的随意进食量。在雄性大鼠中，腹腔注射0.25至1微克/千克的CCK - 8可使30分钟的进食量显著减少，且呈剂量依赖性。CCK - 8的饱腹感效应被特异性胆囊收缩素受体拮抗剂L - 364,718（20纳摩尔/千克）阻断。在雌性大鼠中，动情前期和动情期的进食量显著低于动情间期。在喂食前腹腔注射CCK - 8可使动情间期和动情后期雌性大鼠的进食量显著减少，但在动情前期和动情期则不受影响。CCK - 8对动情间期和动情后期进食量的影响呈剂量依赖性，当同时给予20纳摩尔/千克的L - 364,718时，这种影响几乎消失。本研究结果表明，发情周期阶段会影响大鼠的摄食行为。此外，胆囊收缩素对摄食行为的调节作用在动情间期和动情后期似乎有效，但在动情前期和动情期则无效。
