C反应蛋白能否预测子痫前期复发？
Does C-reactive protein predict recurrent preeclampsia?
作者信息
Gammill Hilary S, Powers Robert W, Clifton Rebecca G, Van Dorsten J Peter, Klebanoff Mark A, Lindheimer Marshall D, Sibai Baha, Landon Mark B, Miodovnik Menachem, Dombrowski Mitchell
机构信息
Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, PA, USA.
出版信息
Hypertens Pregnancy. 2010;29(4):399-409. doi: 10.3109/10641950903214633.
Abstract
OBJECTIVE
Evaluate association of the inflammatory marker C-reactive protein with recurrent preeclampsia.
METHODS
Serum samples collected longitudinally in women with previous preeclampsia from the Maternal-Fetal Medicine Units Network trial of aspirin to prevent preeclampsia were assayed for CRP.
RESULTS
Of 255 women studied, 50 developed recurrence. Baseline C-reactive protein concentration was similar between women who did and did not recur. After adjusting for confounders, neither elevated baseline C-reactive protein nor its change over gestation was associated with recurrence.
CONCLUSION
In this group of women with previous preeclampsia, neither baseline C-reactive protein concentration nor change in concentration over gestation was associated with recurrent preeclampsia.
摘要
目的
评估炎症标志物C反应蛋白与子痫前期复发的相关性。
方法
对参加预防子痫前期阿司匹林治疗的母胎医学单位网络试验中曾患子痫前期的女性纵向采集的血清样本进行C反应蛋白检测。
结果
在研究的255名女性中，50名出现复发。复发组和未复发组女性的基线C反应蛋白浓度相似。在对混杂因素进行校正后，基线C反应蛋白升高及其孕期变化均与复发无关。
结论
在这组曾患子痫前期的女性中，基线C反应蛋白浓度及其孕期浓度变化均与子痫前期复发无关。
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