Post R M, Stoddard F J, Gillin J C, Buchsbaum M S, Runkle D C, Black K E, Bunney W E
Arch Gen Psychiatry. 1977 Apr;34(4):470-7. doi: 10.1001/archpsyc.1977.01770160104009.
Biochemical and electrophysiological factors were studied longitudinally in a rapidly cycling manic-depressive patient. Slow changes in mood, motor activity, sleep, and urinary norepinephrine levels during the course of each depressed and manic episode are reported, as well as rapid alterations in many variables at the time of mood switch. Urinary concentrations of norepinephrine and its metabolite, 3-methoxy-4-hydroxyphenyl glycol (MHPG) were significantly lower in depression than in mania; norepinephrine but not MHPG excretion increased prior to the switch. We postulate that the slow behavioral and biological changes preceding switches in this patient are an important manifestation of the cyclic process in manic-depressive illness.
对一名快速循环型躁郁症患者进行了生化和电生理因素的纵向研究。报告了每次抑郁和躁狂发作过程中情绪、运动活动、睡眠和尿去甲肾上腺素水平的缓慢变化，以及情绪转换时许多变量的快速改变。抑郁期尿中去甲肾上腺素及其代谢产物3-甲氧基-4-羟基苯乙二醇（MHPG）的浓度显著低于躁狂期；转换前去甲肾上腺素排泄增加，但MHPG排泄未增加。我们推测，该患者转换前缓慢的行为和生物学变化是躁郁症周期性过程的重要表现。
