Crowley T J, Macdonald M J, Wagner J E, Zerbe G
Psychopharmacology (Berl). 1985;86(4):458-63. doi: 10.1007/BF00427908.
Outpatients receiving daily methadone-maintenance treatment were crossed over to alternating-day doses of 1-alpha-acetylmethadol, receiving placebo on between-dose days. Spontaneous motility was dramatically higher on acetylmethadol dose days than on placebo days; activity on methadone days was intermediate between these extremes. Patients reported less vigor, more fatigue, and fewer ejaculations on placebo days than on acetylmethadol days, and patients' mood while on this drug was slightly euphoric in comparison to methadone. These effects are subtle, but such drug-induced variations in day-to-day behavior might adversely affect social interactions.
接受每日美沙酮维持治疗的门诊患者被改为隔日服用1-α-乙酰美沙酮，在非服药日服用安慰剂。在服用乙酰美沙酮的日子里，自发运动显著高于服用安慰剂的日子；服用美沙酮日子的活动水平介于这两个极端之间。患者报告称，与服用乙酰美沙酮的日子相比，在服用安慰剂的日子里活力更低、疲劳感更强、射精次数更少，而且与美沙酮相比，服用这种药物时患者的情绪略显欣快。这些影响很细微，但这种药物引起的日常行为变化可能会对社交互动产生不利影响。
