Torres Jesús, Tamimi Faleh, Garcia Ignacio, Herrero Alicia, Rivera Begoña, Sobrino Jose Andrés, Hernández Gonzalo
Department of Health Sciences III, Faculty of Health Sciences, Rey Juan Carlos University, Madrid, Spain.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Mar;107(3):387-92. doi: 10.1016/j.tripleo.2008.11.024.
Paget disease (PD) is an idiopathic disorder characterized by progressive enlargement and deformity of bones, resulting in structural weakness that may be unfavorable for the placement of osseointegrated dental implants. Currently, bisphosphonates are administered for the treatment of PD. However, the use of bisphosphonates has been associated with the onset of osteonecrosis of the jaws. This report deals with a case of a 64-year-old caucasian woman diagnosed with polyostotic PD 17 years earlier who had been treated with bisphosphonates for 7 years. The patient was referred for implant treatment, and after initial placement of 6 fixtures, the postoperative course was uneventful and no complications were registered during a follow-up period of 4 years. Within the limitations of this case, we report that dental implants can be successfully placed and loaded in patients suffering from PD without discontinuing the treatment with bisphosphonates, as long as the patient is not complaining from any additional unfavorable conditions. To the best of our knowledge, this is a unique case describing the successful placement of dental implants in a patient with PD treated with bisphosphonates. Nevertheless, more studies would be needed to optimize the clinical guidelines for the treatment of these patients.
佩吉特病（PD）是一种特发性疾病，其特征为骨骼进行性增大和畸形，导致结构薄弱，这可能不利于骨结合牙种植体的植入。目前，双膦酸盐类药物用于治疗佩吉特病。然而，双膦酸盐类药物的使用与颌骨坏死的发生有关。本报告涉及一名64岁的白种女性，17年前被诊断为多骨型佩吉特病，已接受双膦酸盐类药物治疗7年。该患者因种植治疗前来就诊，在最初植入6颗种植体后，术后过程顺利，在4年的随访期内未出现并发症。在本病例的局限性范围内，我们报告，只要患者没有任何其他不利情况，在不停止双膦酸盐类药物治疗的情况下，患有佩吉特病的患者也可以成功植入和加载牙种植体。据我们所知，这是一个独特的病例，描述了在接受双膦酸盐类药物治疗的佩吉特病患者中成功植入牙种植体的情况。然而，还需要更多的研究来优化这些患者的临床治疗指南。
