Lau Sean K
Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA.
Diagn Cytopathol. 2009 May;37(5):359-64. doi: 10.1002/dc.21015.
The plasmacytoid variant of urothelial carcinoma is an uncommon form of urothelial carcinoma with a distinctive histologic appearance. Descriptions of the cytologic features of this particular type of urothelial carcinoma in urinary specimens are limited. The present report details the urinary cytomorphologic findings of a plasmacytoid urothelial carcinoma occurring in the urinary bladder of a 66-year-old male. Bladder washings showed the presence of scattered dyscohesive cells with a plasmacytoid appearance characterized by abundant amounts of cytoplasm, eccentrically located nuclei, and inconspicuous nucleoli. The diagnosis of plasmacytoid urothelial carcinoma was confirmed upon histologic examination of a concurrently performed transurethral resection specimen, with immunohistochemical studies supporting this interpretation. Although rare, the plasmacytoid variant of urothelial carcinoma should be a diagnostic consideration when atypical cells with plasmacytoid features are encountered in a urinary specimen.
尿路上皮癌的浆细胞样变体是尿路上皮癌的一种罕见形式，具有独特的组织学表现。关于这种特殊类型尿路上皮癌在尿液标本中的细胞学特征描述有限。本报告详细阐述了一名66岁男性膀胱发生的浆细胞样尿路上皮癌的尿液细胞形态学发现。膀胱冲洗液显示存在散在的、细胞间缺乏黏附性的细胞，呈浆细胞样外观，其特征为胞质丰富、核偏位且核仁不明显。经同时进行的经尿道切除标本的组织学检查确诊为浆细胞样尿路上皮癌，免疫组化研究支持这一诊断。尽管罕见，但当在尿液标本中遇到具有浆细胞样特征的非典型细胞时，浆细胞样尿路上皮癌应作为一种诊断考虑。
