Mai Kien T, Park Paul C, Yazdi Hossein M, Saltel Eric, Erdogan Seyda, Stinson William A, Cagiannos Ilias, Morash Christopher
Department of Laboratory Medicine, Division of Anatomical Pathology, The Ottawa Hospital and Department of Pathology and Laboratory Medicine, University of Ottawa, Ontario, Canada.
Eur Urol. 2006 Nov;50(5):1111-4. doi: 10.1016/j.eururo.2005.12.047. Epub 2006 Jan 18.
Plasmacytoid urothelial carcinoma (PUC) is a rare tumor of the urinary bladder. Its clinical and histopathological features have not been well characterized. In this study we report seven cases of PUC from our institution.
A pilot case of PUC was recently diagnosed at our institution. Cases of urothelial carcinoma (UC) were reviewed for a period of seven years to identify PUC. Representative sections from each case of PUC were submitted for immunohistochemical studies. Clinical charts were reviewed.
There were a total of seven cases of PUC out of 260 cases of invasive urothelial carcinoma. The common type of urothelial carcinoma (CUC) was present in focal areas in five cases. Cases with extensive PUC showed coarse and indurated mucosal folds and thickened bladder walls, with no grossly identifiable tumor. Urine cytology showed a scant number of atypical single cells, frequently without tumor diathesis, leading to a shortfall in the positive cytological diagnosis. Histologically, PUC appeared as dyscohesive, plasmacytoid cells with eccentric nuclei, extending widely into the bladder walls and extensively into adjacent pelvic organs.
PUC is a distinct clinical and pathological subtype of urothelial carcinoma. The clinical presentation is frequently late due to the frequent absence of hematuria and indurated mucosal surface at cystoscopy. The disease followed an ominous course with recurrence in all the patients, and with patient death.
浆细胞样尿路上皮癌（PUC）是一种罕见的膀胱肿瘤。其临床和组织病理学特征尚未得到充分描述。在本研究中，我们报告了来自我们机构的7例PUC病例。
我们机构最近诊断出一例PUC试点病例。对尿路上皮癌（UC）病例进行了为期七年的回顾，以识别PUC。将每例PUC的代表性切片提交进行免疫组织化学研究。查阅了临床病历。
在260例浸润性尿路上皮癌中，共有7例PUC。5例在局灶区域存在常见类型的尿路上皮癌（CUC）。PUC广泛的病例显示黏膜皱襞粗糙、硬结，膀胱壁增厚，肉眼无法识别肿瘤。尿液细胞学检查显示少量非典型单个细胞，通常无肿瘤素质，导致细胞学阳性诊断不足。组织学上，PUC表现为细胞间缺乏黏附性的浆细胞样细胞，核偏位，广泛延伸至膀胱壁并广泛侵犯相邻盆腔器官。
PUC是尿路上皮癌一种独特的临床和病理亚型。由于膀胱镜检查时经常没有血尿和黏膜表面硬结，临床表现通常较晚。该疾病预后不佳，所有患者均复发，并导致患者死亡。
