Azañero W D, Mazzonetto R, León J E, Vargas P A, Lopes M A, de Almeida O P
Department of Oral Medicine, Oral Surgery and Oral Pathology, Faculty of Stomatology, University Cayetano Heredia, 430, Lima, Perú.
Int J Oral Maxillofac Surg. 2009 Apr;38(4):388-92. doi: 10.1016/j.ijom.2009.01.003. Epub 2009 Feb 13.
Cysts of the tongue are rare, usually derived from epithelia of the embryonic gastrointestinal and respiratory tracts, and classified according to the predominant epithelium lining. These cysts are usually discovered during infancy, more frequently in males, but they may not appear until well into adulthood. The authors report two lingual cysts lined mainly with respiratory, and focally by squamous, epithelium. Periodic acid-Schiff and mucicarmine staining revealed focal positivity in intracystic mucoid material and goblet cells. Immunohistochemical analysis with vimentin, cytokeratins (AE1/AE3, 34betaE12, CK1, CK5, CK6, CK7, CK8, CK10, CK13, CK14, CK16, CK18, and CK19), E-cadherin, beta-catenin, and epithelial membrane antigen showed a similar profile of normal respiratory epithelium, suggesting well-differentiated states. Owing to their controversial origin, these cysts should be named descriptively, as suggested by Manor et al., as lingual cysts with respiratory epithelium.
舌囊肿较为罕见，通常源自胚胎期胃肠道和呼吸道的上皮组织，并根据内衬的主要上皮类型进行分类。这些囊肿通常在婴儿期被发现，男性更为常见，但也可能直到成年期才出现。作者报告了两例主要内衬呼吸道上皮且局灶性为鳞状上皮的舌囊肿。过碘酸希夫染色和黏液卡红染色显示囊内黏液样物质和杯状细胞呈局灶阳性。用波形蛋白、细胞角蛋白（AE1/AE3、34βE12、CK1、CK5、CK6、CK7、CK8、CK10、CK13、CK14、CK16、CK18和CK19）、E-钙黏蛋白、β-连环蛋白和上皮膜抗原进行免疫组化分析，显示出与正常呼吸道上皮相似的特征，提示分化良好。由于其起源存在争议，按照马诺尔等人的建议，这些囊肿应采用描述性命名，即呼吸道上皮舌囊肿。
