单克隆抗体与狂犬病病毒的结合特性
Binding properties of monoclonal antibodies to rabies virus.
作者信息
Cusi M G, Valensin P E, Tollis M, Bracci L, Petreni S, Soldani P
机构信息
Dipartimento di Biologia Molecolare, Università degli Studi di Siena, Italy.
出版信息
Microbiologica. 1991 Jul;14(3):205-11.
PMID:1921740
Abstract
The monoclonal antibodies (mAbs) obtained by immunizing mice with a tetradecapeptide corresponding to the 190-203 region of rabies virus glycoprotein, involved in binding to the acetylcholine receptor (AchR), displayed different specificities to different rabies virus strains. These mAbs, when used in immunofluorescence tests, allowed differentiation of wild rabies viruses from the attenuated ones.
摘要
用与狂犬病病毒糖蛋白190 - 203区域对应的十四肽免疫小鼠获得的单克隆抗体（mAb），参与与乙酰胆碱受体（AchR）结合，对不同的狂犬病病毒株表现出不同的特异性。这些单克隆抗体用于免疫荧光试验时，可区分野生狂犬病病毒和减毒狂犬病病毒。
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