SUMO在光感受器的结局中发挥作用。
SUMO weighs in on a photoreceptor finish.
作者信息
LaBonne Carole
出版信息
Dev Cell. 2009 Feb;16(2):165-6. doi: 10.1016/j.devcel.2009.01.017.
PMID:19217419
Abstract
In the developing retina the nuclear hormone receptor Nr2e3 has dual roles, promoting expression of rod-specific genes and repressing expression of cone specific genes. In a recent issue of Neuron, Onishi et al. show that PIAS3-mediated SUMOylation of Nr2e3 plays an essential role in the specification of rod photoreceptors by converting Nr2e3 to a potent repressor of cone gene expression.
摘要
在发育中的视网膜中，核激素受体Nr2e3具有双重作用，既促进视杆细胞特异性基因的表达，又抑制视锥细胞特异性基因的表达。在最近一期的《神经元》杂志上，大西等人表明，PIAS3介导的Nr2e3的SUMO化通过将Nr2e3转化为视锥细胞基因表达的有效抑制因子，在视杆光感受器的特化中起关键作用。
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