Nelson Harold S
Department of Medicine, National Jewish Health, Denver, CO 80206, USA.
J Allergy Clin Immunol. 2009 Apr;123(4):763-9. doi: 10.1016/j.jaci.2008.12.013. Epub 2009 Feb 13.
The English and non-English language literature on allergen immunotherapy was reviewed for studies simultaneously using 2 or more distinct allergen extracts in either subcutaneous or sublingual immunotherapy. Thirteen studies were identified, 11 using subcutaneous injections, 1 using sublingual administration, and 1 using both. In studies with adequate information, administration of 2 extracts by means of either subcutaneous immunotherapy or sublingual immunotherapy was effective. In studies using multiple allergens, 3 studies showed clear efficacy, whereas in the other 2 studies, lack of efficacy might have been due to inadequate doses of extract or omission of clinically relevant allergens in the treatment regimen. It is concluded that simultaneous administration of more than 1 allergen extract is clinically effective. However, more studies are needed, particularly with more than 2 allergen extracts and with sublingual administration.
我们检索了英文和非英文的变应原免疫疗法文献，以查找在皮下或舌下免疫疗法中同时使用2种或更多种不同变应原提取物的研究。共识别出13项研究，其中11项使用皮下注射，1项使用舌下给药，1项同时使用了这两种方法。在有足够信息的研究中，通过皮下免疫疗法或舌下免疫疗法给予2种提取物是有效的。在使用多种变应原的研究中，3项研究显示出明显疗效，而在其他2项研究中，疗效不佳可能是由于提取物剂量不足或治疗方案中遗漏了临床相关变应原。结论是同时给予1种以上变应原提取物在临床上是有效的。然而，还需要更多的研究，特别是使用2种以上变应原提取物以及舌下给药的研究。
