González Miguel A, Correa-Royero Julieth, Agudelo Lee, Mesa Ana, Betancur-Galvis Liliana
Departamento de Química Orgánica, Universidad de Valencia, Dr. Moliner 50, E-46100 Burjassot, Valencia, Spain.
Eur J Med Chem. 2009 Jun;44(6):2468-72. doi: 10.1016/j.ejmech.2009.01.014. Epub 2009 Jan 24.
A series of C18-oxygenated derivatives of abietic acid were synthesized and evaluated for their cytotoxic, antimycotic, and antiviral activities. In general, the introduction of an aldehyde group at C18 did improve the resultant bioactivity, while the presence of an acid or alcohol led to less active compounds.
合成了一系列枞酸的C18-氧化衍生物，并对其细胞毒性、抗真菌和抗病毒活性进行了评估。一般来说，在C18位引入醛基确实提高了所得生物活性，而存在酸或醇则导致化合物活性较低。
