Heida James G, Moshé Solomon L, Pittman Quentin J
The Saul R. Korey Department of Neurology, Laboratory of Developmental Epilepsy, The Montefiore/Einstein Epilepsy Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Brain Dev. 2009 May;31(5):388-93. doi: 10.1016/j.braindev.2008.11.013. Epub 2009 Feb 13.
Febrile seizures (FS) occur in children as a result of fever. Despite their prevalence, the pathophysiology of FS has remained unclear. Recent evidence from clinical and experimental studies has highlighted a potential role of immune generated products in the genesis of FS. Of particular interest are the pro-inflammatory cytokine, interleukin-1beta (IL-1beta) and its naturally occurring antagonist, interleukin 1 receptor antagonist (IL-1ra). Using a novel animal model of FS, involving the generation of physiological fever, we investigated the role of the IL-1beta/IL-1ra system in the genesis of FS. We found that animals with FS had increased hippocampal and hypothalamic IL-1beta compared to equally treated animals without FS, which was first evident at onset of FS in the hippocampus. There were no differences in IL-1ra levels. ICV IL-1beta increased the number of animals with FS while IL-1ra had an opposite anti-convulsant effect. The data from these studies, in combination with recent results from other laboratories, have established a putative role for the IL-1beta/IL-1ra system in the genesis of FS.
热性惊厥（FS）在儿童中因发热而发生。尽管其很常见，但FS的病理生理学仍不清楚。临床和实验研究的最新证据突出了免疫产生的产物在FS发生中的潜在作用。特别令人感兴趣的是促炎细胞因子白细胞介素-1β（IL-1β）及其天然存在的拮抗剂白细胞介素1受体拮抗剂（IL-1ra）。使用一种新型的FS动物模型，该模型涉及生理性发热的产生，我们研究了IL-1β/IL-1ra系统在FS发生中的作用。我们发现，与同样接受治疗但无FS的动物相比，患有FS的动物海马体和下丘脑的IL-1β增加，这在海马体中FS发作时首次明显。IL-1ra水平没有差异。脑室内注射IL-1β增加了患有FS的动物数量，而IL-1ra具有相反的抗惊厥作用。这些研究的数据，与其他实验室的最新结果相结合，确立了IL-1β/IL-1ra系统在FS发生中的假定作用。
