110例早期自然流产绒毛细胞培养及核型分析

[Chorionic villus cell culture and karyotype analysis in 110 cases of early spontaneous abortion].

作者信息

Xiong Li, Liu Jie, Deng Kang, Liu Si-ping, Jia Bei, Wu Rui-feng, Zhong Mei, Zeng Rong

机构信息

Basic Medical Experiment Teaching Center, Southern Medical University, Guangzhou 510515, China.

出版信息

Nan Fang Yi Ke Da Xue Xue Bao. 2009 Jan;29(1):64-7.

PMID:19218115

Abstract

OBJECTIVE

To investigate the value of fetal chromosomal karyotype analysis in cases of early spontaneous abortion.

METHODS

Chorionic villus specimens obtained from 110 cases of early spontaneous abortion were cultured for karyotype analysis.

RESULTS

Of the 110 cases, chorionic villus was successfully cultured in 103 cases (93.7%), and abnormal embryo karyotypes were identified in 52 cases (50.5%). Trisomy was the most frequent embryo karyotype abnormalities in these cases, and chromosomal aberration occurred in 29 cases (52.9%) of the first spontaneous abortion and in 23 cases (42.6%) of repeated abortions. Female fetuses accounted for 75.5% (78 cases) in the spontaneously aborted fetuses and for 67.3% (35 cases) in fetuses with chromosomal abnormalities.

CONCLUSION

Embryo chromosomal abnormality is the most important reason of early spontaneous abortion, and karyotype analysis of the villus helps identify the causes of abortion and ensure the success of the next pregnancy.

摘要

目的

探讨胎儿染色体核型分析在早期自然流产病例中的价值。

方法

对110例早期自然流产病例获取的绒毛组织标本进行培养并进行核型分析。

结果

110例中，103例（93.7%）绒毛组织成功培养，52例（50.5%）鉴定出胚胎核型异常。三体是这些病例中最常见的胚胎核型异常，首次自然流产病例中染色体畸变发生在29例（52.9%），反复流产病例中发生在23例（42.6%）。自然流产胎儿中女性胎儿占75.5%（78例），染色体异常胎儿中占67.3%（35例）。