Zhang Hua-kun, Luo Fu-wei, Geng Qian, Li Juan, Liu Qing-zhi, Chen Wu-bin, Li Fang, Xie Jian-sheng
Southern Medical University, Shenzhen, Guangdong, People's Republic of China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2011 Oct;28(5):575-8. doi: 10.3760/cma.j.issn.1003-9406.2011.05.024.
To investigate the relationship between fetal chromosomal karyotype and early spontaneous abortion, and the effect of the environmental factors on spontaneous abortion.
Choronic villi from 252 cases of missed abortion were sampled as patient group and 50 normal pregnancies as control group. Chorionic villi were cultured and karyotype analysis was performed by G-banding. Clinical information was collected.
The rate of chorion chromosome abnormality in the patient group was 58.09%, significantly higher than that in the control group (4.17%) (P<0.01). Among the 140 cases of karyotype abnormalities, 81 were trisomy, 29 were monosomy X and 17 were polyploidy, accounting for 57.86%, 20.71% and 12.14% of total abnormalities, respectively. Long time and low dose radiation exposure of the pregnant female seemed to be related with spontaneous abortion(P<0.01).
Chorion chromosome abnormality is a major reason of early spontaneous abortion and karyotype analysis of chorionic villus is of clinical importance. For pregnant women, long-term exposure to computers and television seems a risk factor for missed abortion.
探讨胎儿染色体核型与早期自然流产的关系以及环境因素对自然流产的影响。
选取252例稽留流产患者的绒毛作为病例组，50例正常妊娠者的绒毛作为对照组。对绒毛进行培养，采用G显带技术进行核型分析，并收集临床资料。
病例组绒毛染色体异常率为58.09%，显著高于对照组（4.17%）（P<0.01）。在140例核型异常病例中，三体81例，X单体29例，多倍体17例，分别占异常总数的57.86%、20.71%和12.14%。孕妇长时间低剂量辐射暴露似乎与自然流产有关（P<0.01）。
绒毛染色体异常是早期自然流产的主要原因，绒毛核型分析具有临床意义。对于孕妇，长期接触电脑和电视似乎是稽留流产的一个危险因素。
