Du Xiao-hong, Liang Fei-yu, Zhao Xiao-wei
Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2009 Jan;29(1):154-5, 159.
To investigate the therapeutic effects of phosphocreatine in elderly patients with chronic congestive heart failure (CHF) and its effects on plasma brain natriuretic peptide (BNP).
Forty elderly patients with chronic CHF were randomly divided into two groups to receive basic treatment (control group) and additional phosphocreatine treatment (treatment group) with a treatment course of 8 weeks. The patients were evaluated for improvement in New York Heart Association (NYHA) functional class, symptoms, left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), and left ventricular ejection fraction (LVEF) and the levels of BNP before and after treatment.
After 8 weeks of treatment, the overall efficacy rate was significantly higher in treatment group than in the control group, and LVESD, LVEDD, LVEF and BNP level of the treatment group were significantly lowered in comparison with those of the control group (P<0.05).
Phosphocreatine in addition to the basic treatment can reduce the BNP level and improve the cardiac systolic and diastolic function in elderly patients with chronic CHF.
探讨磷酸肌酸对老年慢性充血性心力衰竭（CHF）患者的治疗效果及其对血浆脑钠肽（BNP）的影响。
将40例老年慢性CHF患者随机分为两组，分别接受基础治疗（对照组）和加用磷酸肌酸治疗（治疗组），疗程8周。评估患者纽约心脏协会（NYHA）心功能分级、症状、左心室舒张末期内径（LVEDD）、左心室收缩末期内径（LVESD）、左心室射血分数（LVEF）的改善情况以及治疗前后BNP水平。
治疗8周后，治疗组总有效率显著高于对照组，且治疗组LVESD、LVEDD、LVEF及BNP水平较对照组显著降低（P<0.05）。
在基础治疗的基础上加用磷酸肌酸可降低老年慢性CHF患者的BNP水平，改善心脏收缩和舒张功能。
