Hausenloy Derek J, Yellon Derek M
The Hatter Cardiovascular Institute, University College London Hospital and Medical School, 67 Chenies Mews, London WC1E 6HX, UK.
Cardiovasc Res. 2009 Jul 15;83(2):179-94. doi: 10.1093/cvr/cvp062. Epub 2009 Feb 13.
Many of the originally identified cardiovascular 'growth factors' have been demonstrated to exert a diverse variety of actions within the cardiovascular system, the majority of which are unrelated to their initially proposed mechanism of action. Interestingly, several of these growth factors have been demonstrated to protect the cardiomyocyte from the detrimental effects of acute ischaemia-reperfusion injury, through the activation of a variety of cell-surface receptors and the subsequent recruitment of a number of intracellular signal transduction pathways, which include components of the reperfusion injury salvage kinase pathway. This article will review several of these cardioprotective growth factors with respect to their ability to confer direct myocardial protection, focusing on the underlying signalling pathways involved and their potential for clinical application.
许多最初被鉴定出的心血管“生长因子”已被证明在心血管系统中发挥着多种多样的作用，其中大多数作用与其最初提出的作用机制无关。有趣的是，已证明其中几种生长因子可通过激活多种细胞表面受体并随后募集多种细胞内信号转导途径（包括再灌注损伤挽救激酶途径的成分）来保护心肌细胞免受急性缺血 - 再灌注损伤的有害影响。本文将就几种具有直接心肌保护作用的生长因子进行综述，重点关注其潜在的信号转导途径及其临床应用潜力。
