Nosal S, Durdik P, Luptakova A, Sutovska M, Nosal V, Jesenak M, Havlicekova Z, Hamzik J, Banovcin P
Pediatric Clinic, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.
J Physiol Pharmacol. 2008 Dec;59 Suppl 6:43-51.
The course of a respiratory disorder in a child may end up in respiratory failure. There are also acute non-respiratory diseases which have a great influence on the respiratory functions and often lead to the acute lung injury and sometimes to the acute respiratory distress syndrome (ARDS). A feature of respiratory function deterioration is changed in the surfactant system. We often see inhibition of its synthesis or damage to its structure. Therapy of children suffering from ARDS should be complex and rapid. Despite many recently published studies explaining the principle of this disorder, the mortality of ARDS is still very high (30-50%). There are several studies documenting successful administration of exogenous surfactant as part of a complex combined therapy of patients with ARDS, which leads to decreased mortality, improved oxygenation, and decreased need for aggressive artificial pulmonary ventilation. The authors of this article present their own experience with administration of exogenous surfactant in therapy of children with ARDS.
儿童呼吸系统疾病的病程最终可能会发展为呼吸衰竭。也有一些急性非呼吸系统疾病对呼吸功能有很大影响，常常导致急性肺损伤，有时还会引发急性呼吸窘迫综合征（ARDS）。呼吸功能恶化的一个特征是表面活性剂系统发生变化。我们经常会看到其合成受到抑制或结构遭到破坏。患有ARDS的儿童的治疗应该是综合且迅速的。尽管最近有许多研究解释了这种疾病的原理，但ARDS的死亡率仍然非常高（30% - 50%）。有多项研究记录了在ARDS患者的综合联合治疗中成功使用外源性表面活性剂的情况，这导致了死亡率降低、氧合改善以及对积极的人工肺通气需求的减少。本文的作者介绍了他们在给患有ARDS的儿童使用外源性表面活性剂进行治疗方面的经验。
