Calkovska A, Engler I, Mokra D, Drgova A, Sivonova M, Tartarkova Z, Calkovsky V, Brozmanova M, Tatar M
Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia.
J Physiol Pharmacol. 2008 Dec;59 Suppl 6:173-81.
Inhalation of partially ionized oxygen may have less adverse effects on lung functions than medical oxygen. Guinea pigs inhaled air, 100% molecular medical oxygen (O(2)mol), partially negatively (O(2)neg) or positively (O(2)posit) ionized oxygen during 17 and 60 h. After 17 h, dityrosines, markers of oxidative injury, in lung homogenate increased in O(2)neg and decreased in O(2)posit groups vs. controls. After 60 h, dityrosines rose after inhalation of O(2)mol and O(2)neg, but not in the O(2)posit group. Lysine-LPO products increased and lung wet/dry weight ratio decreased in O(2)mol and O(2)neg, and not in O(2)posit group. Relative neutrophil count in BALF was elevated in all oxygen-treated groups with lower numbers in O(2)posit vs.O(2)mol and O(2)neg groups. After 60 h, surfactant activity was better in O(2)posit vs. O(2)mol group. In conclusion, long-term inhalation of partially positively ionized oxygen is associated with less oxidative stress, milder lung inflammatory response, and better surfactant activity than molecular or negatively ionized oxygen.
吸入部分电离的氧气对肺功能的不良影响可能比医用氧气小。豚鼠在17小时和60小时内吸入空气、100%分子态医用氧气（O₂mol）、部分带负电（O₂neg）或带正电（O₂posit）的电离氧气。17小时后，与对照组相比，肺匀浆中氧化损伤标志物二酪氨酸在O₂neg组增加，在O₂posit组减少。60小时后，吸入O₂mol和O₂neg后二酪氨酸升高，但O₂posit组未升高。O₂mol和O₂neg组赖氨酸-LPO产物增加，肺湿/干重比降低，而O₂posit组未出现这种情况。所有氧气处理组BALF中的中性粒细胞相对计数均升高，O₂posit组的中性粒细胞数量低于O₂mol和O₂neg组。60小时后，O₂posit组的表面活性剂活性优于O₂mol组。总之，与分子态或带负电的电离氧气相比，长期吸入部分带正电的电离氧气与较低的氧化应激、较轻的肺部炎症反应和更好的表面活性剂活性相关。
