Grabczak E M, Dabrowska M, Krenke R, Domeracka-Kolodziej A, Domagala-Kulawik J, Arcimowicz M, Hamera M, Chazan R
Department of Internal Medicine, Pneumonology and Allergology, Medical University of Warsaw, Poland.
J Physiol Pharmacol. 2008 Dec;59 Suppl 6:285-96.
The objective of the present study was to evaluate the prevalence of chronic cough causes and to compare the efficacy of two diagnostic approaches used in ambulatory vs. hospitalized setting. Eighty patients with chronic cough, 40 in each group, were enrolled into the study. The etiology of cough was determined on medical history and on either basic (in out-patients) or detailed (in in-patients) investigations on most common causes of chronic cough. We diagnosed etiology of cough in all subjects. The most frequent causes of cough were gastroesophageal reflux disease (GERD) and upper airway cough syndrome (UACS). Nonasthmatic eosinophilic bronchitis (NAEB) and multiple cough causes were recognized more often in hospitalized patients (P<0.05). We conclude that the main causes of chronic cough were GERD and UACS. An extensive diagnostic approach allows recognizing NEAB more frequently and reveals the complex nature of chronic cough.
本研究的目的是评估慢性咳嗽病因的患病率，并比较在门诊与住院环境中使用的两种诊断方法的疗效。80例慢性咳嗽患者被纳入研究，每组40例。根据病史以及对慢性咳嗽最常见病因的基本（门诊患者）或详细（住院患者）检查来确定咳嗽的病因。我们对所有受试者的咳嗽病因进行了诊断。咳嗽最常见的病因是胃食管反流病（GERD）和上气道咳嗽综合征（UACS）。非哮喘性嗜酸性粒细胞性支气管炎（NAEB）和多种咳嗽病因在住院患者中更常被识别（P<0.05）。我们得出结论，慢性咳嗽的主要病因是GERD和UACS。广泛的诊断方法能够更频繁地识别NAEB，并揭示慢性咳嗽的复杂性。
