Aksamija Alenka, Habek Dubravko, Stanojević Milan, Ujević Boris
Clinic of Gynecology and Obstetrics, Sveti Duh General Hospital, Zagreb, Croatia.
Fetal Diagn Ther. 2009;25(1):79-82. doi: 10.1159/000201945. Epub 2009 Feb 13.
The use of antiepileptic drugs (AEDs) during pregnancy has been associated with an increased risk of major and minor fetal malformations. This paper describes 2 infants with malformations born to epileptic mothers who used AEDs throughout pregnancy. In the first case, the AED used for seizure control was methylphenobarbital, while in the second case the patient had been prescribed carbamazepine. We noted major and minor congenital malformations in both infants exposed in utero to these anticonvulsant drugs. Pregnant women still experience poor obstetrical care because they report to tertiary centers at the end of their pregnancy or when in labor, making it difficult to provide proper medical care for both the infant and the mother.
孕期使用抗癫痫药物（AEDs）与胎儿出现严重和轻微畸形的风险增加有关。本文描述了2例畸形婴儿，其母亲为癫痫患者，在整个孕期都使用了AEDs。第一例中，用于控制癫痫发作的AED是甲基苯巴比妥，而在第二例中，患者服用的是卡马西平。我们注意到，这两名在子宫内接触过这些抗惊厥药物的婴儿均出现了严重和轻微的先天性畸形。孕妇仍然得不到良好的产科护理，因为她们在怀孕末期或临产时才前往三级医疗中心，这使得为婴儿和母亲提供适当的医疗护理变得困难。
