Lau Benson W M, Yau Suk-Yu, Lee Tatia M C, Ching Yick-Pang, Tang Siu-Wa, So Kwok-Fai
Department of Anatomy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, Pokfulam, China.
Neuroreport. 2009 Mar 4;20(4):371-7. doi: 10.1097/WNR.0b013e328324edcd.
Adult neurogenesis in hippocampus is associated with behaviors such as learning. Hippocampus is involved in the regulation of prepulse inhibition (PPI), but the relationship between neurogenesis and PPI is unexplored. We conducted four experiments to determine the role of neural progenitor cell proliferation in PPI. Intracerebroventricular infusion of cytostatic cytosine arabinoside caused PPI disruption but repeated exposure to PPI sessions prevented the PPI disruption. Corticosterone treatment, which decreases hippocampal cell proliferation, caused PPI disruption, whereas antidepressant and exercise, which increased cell proliferation, did not affect PPI. These results suggest that cell proliferation is involved in the first encounter with PPI test while its importance may decrease upon repeated exposures to the tests.
海马体中的成体神经发生与学习等行为有关。海马体参与前脉冲抑制（PPI）的调节，但神经发生与PPI之间的关系尚未得到探索。我们进行了四项实验来确定神经祖细胞增殖在PPI中的作用。脑室内注入细胞抑制性阿糖胞苷会导致PPI破坏，但反复暴露于PPI测试中可防止PPI破坏。皮质酮治疗会减少海马体细胞增殖，导致PPI破坏，而抗抑郁药和运动可增加细胞增殖，但不影响PPI。这些结果表明，细胞增殖在首次接触PPI测试时起作用，而在反复接触测试后其重要性可能会降低。
