肾压力感受器位于何处，又是由什么构成？连接蛋白假说。
Who and where is the renal baroreceptor?: the connexin hypothesis.
作者信息
Gomez R Ariel, Sequeira Lopez Maria Luisa S
机构信息
Department of Pediatrics, University of Virginia Medical Center, Charlottesville, Virginia 22908, USA.
出版信息
Kidney Int. 2009 Mar;75(5):460-2. doi: 10.1038/ki.2008.536.
Abstract
Gap junctions are emerging as a fundamental mechanism for the control of renin synthesis and release. Connexin40 is prominent in juxtaglomerular cells. When missing, it results in hyperreninemia and hypertension. Schweda et al. offer exciting data demonstrating that connexin45, a connexin with different biophysical properties, can replace connexin40 functions related to the control of renin.
摘要
缝隙连接正逐渐成为控制肾素合成与释放的一种基本机制。连接蛋白40在球旁细胞中很突出。缺失时，会导致高肾素血症和高血压。施韦达等人提供了令人兴奋的数据，证明具有不同生物物理特性的连接蛋白45可以替代与肾素控制相关的连接蛋白40的功能。
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本文引用的文献
1
Substitution of connexin40 with connexin45 prevents hyperreninemia and attenuates hypertension.用连接蛋白45替代连接蛋白40可预防高肾素血症并减轻高血压。
Kidney Int. 2009 Mar;75(5):482-9. doi: 10.1038/ki.2008.637. Epub 2008 Dec 24.
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Connexons and cell adhesion: a romantic phase.连接子与细胞黏附：一个浪漫的阶段。
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Gap junctions: multifaceted regulators of embryonic cortical development.间隙连接：胚胎皮质发育的多面调节因子
Trends Neurosci. 2008 May;31(5):243-50. doi: 10.1016/j.tins.2008.02.007. Epub 2008 Apr 9.
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Function of connexins in the renal circulation.连接蛋白在肾循环中的功能。
Kidney Int. 2008 Mar;73(5):547-55. doi: 10.1038/sj.ki.5002720. Epub 2007 Dec 12.
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Expression and role of connexins in the rat renal vasculature.连接蛋白在大鼠肾血管系统中的表达及作用
Kidney Int. 2008 Feb;73(4):415-22. doi: 10.1038/sj.ki.5002673. Epub 2007 Nov 28.
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Pannexins and gap junction protein diversity.泛连接蛋白与间隙连接蛋白的多样性。
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Lack of connexin 40 causes displacement of renin-producing cells from afferent arterioles to the extraglomerular mesangium.连接蛋白40的缺失导致产肾素细胞从入球小动脉移位至球外系膜。
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Connexin40 is essential for the pressure control of renin synthesis and secretion.连接蛋白40对肾素合成与分泌的压力控制至关重要。
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