Araújo-Filho João Alves de, Vasconcelos Arioldo Carvalho, Sousa Eduardo Martins de, Silveira Colombina da, Ribeiro Elisangela, Kipnis André, Junqueira-Kipnis Ana Paula
Institute of Tropical Pathology and Public Health, Federal University of Goiás, GO, Brazil.
Braz J Infect Dis. 2008 Oct;12(5):447-52. doi: 10.1590/s1413-86702008000500019.
Extensively drug-resistant tuberculosis (XDR-TB) is an emerging health problem that threatens tuberculosis (TB) control worldwide, since suitable treatment for this disease has not yet been found. We report a case of secondary pulmonary XDR-TB in a 54-year-old, HIV-negative male from Goiânia, Brazil. The patient had long-standing pulmonary tuberculosis (nine years) with extensive bilateral lung damage and had been treated with multiple antituberculosis drugs (self-administered) before XDR-TB diagnosis. The strain of Mycobacterium tuberculosis was resistant to R- rifampicin, H-isoniazid, E-ethambutol, Eto-ethionamide, Ofx-ofloxacin, and Am-amikacin. This patient died with multiple organ failure due to sepsis secondary to bacterial pneumonia.
广泛耐药结核病（XDR-TB）是一个新出现的健康问题，由于尚未找到针对该病的合适治疗方法，它对全球结核病控制构成威胁。我们报告了一例来自巴西戈亚尼亚的54岁HIV阴性男性继发性肺部广泛耐药结核病病例。该患者患有长期肺结核（九年），双侧肺部有广泛损伤，在广泛耐药结核病诊断之前，曾自行使用多种抗结核药物进行治疗。结核分枝杆菌菌株对利福平（R）、异烟肼（H）、乙胺丁醇（E）、乙硫异烟胺（Eto）、氧氟沙星（Ofx）和阿米卡星（Am）耐药。该患者因细菌性肺炎继发败血症导致多器官衰竭死亡。
